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Interestingly, the histone deacetylase SIRT1 canalso localizes into the PML-NBs and reduce the acetylation of p53 at Lys382 andthereby antagonize the induction of p53 activity [216, 217].

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Interms of PaCO2 levels, the threshold for the CPAPgroup was 65 mmHg (both for intubation and forextubation), while it was 50 mmHg for extuba-tion in the control group (showing that even inthe standard group, higher-than-“normal” PaCO2levels are currently being accepted). Sedentary lifestyleshould be discouraged and regular aerobic exercise shouldbe encouraged. However, researchers could divide it into two or more groups,and select participants on this basis

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2 Replies to “The Crew”

  1. Congratulations to the crew. I really enjoy reading your adventures from time to time and wishing to have a sabbatical year myself. No school could teach you and your children what you have learned in this journey.

  2. Thank You Hortensia ! We are indeed very satisfied with this choice. Particularly the last season, which was when we have been TRULY “out there”, has been a very precious time. The kids are much more appreciative – in general. We have strengthened our relationships in ways we had not experienced before. And then there’s the sense of accomplishment. It’s been cool. More to come this year. Stay tuned !

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